General Medical Questions and Answers # 1

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1.  Who described 'alcoholic polyneuritis' in 1887?
Sergei Sergeievich Korsakoff

2.  What is the mechanism of phenelzine?
Phenelzine a is an MAO inhibitor

3.  What are three interventions that can decrease intracranial intravascular volume?
    * Decreased PCO2---cerebral blood flow is directly proportional to PCO2---so you would want to hyperventilate the patient
    * Vasoconstriction
    * Elevate head

4.  How much must clotting factor activity be decreased before resulting in prolongation in the PTT?
Clotting factor activity levels decreased to 40% or less of the normal activity can result in a prolonged PTT

5. Celiac sprue occurs secondary to sensitivity to gliadin. IgA and IgG anti-gliadin antibodies are increased in more than 90% of patients, but are not specific. What is a better blood test for celiac disease?
IgA endomysial antibodies are the best screening for celiac disease and are more specific for the disorder

6.  How often do patients with rheumatoid arthritis have a positive ANA?
Approximately 30-50% of patients with RA will have a positive ANA

7.  What is the most common cause of cardiac tamponade?
Cancer

8.  What is the malignancy related skin disorder characterized by new onset of large wart-like seborrheic keratosis?
Sign of Leser-Trelat

9.  How does indomethacin effect furosemide?
Indomethacin can decrease the antihypertensive effects of furosemide.

10.  n AML, which chromosome abnormalities are associated with a worse prognosis?
Patients with abnormalities of chromosome 5 or 7 are generally associated with a worse prognosis

11.  List three activities of prostaglandin E2?
    * Vasodilator
    * Natriuretic
    * Contracts the gravid uterus

12.  What is the most common side effect of buspirone?
The most common side effect of buspirone is headaches.

13.  What is the classic triad of Addison's disease?
    * Hyperkalemia
    * Azotemia
    * Hyponatremia

14.  What is the mechanism of thioguanine?
Thioguanine is a purine analogue antimetabolite

15.  How do you determine energy requirements of patient to maintain weight or to gain weight?
    * Maintain weight -- BEE x 1.25
    * Gain weight -- BEE x 1.5

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